Calcium-D-Glucarate is sometimes used by healthcare practitioners to promote optimum liver function, detoxification and reduce excess hormone levels, among other uses
Key Features
- Calcium-D-glucarate is the calcium salt of D-glucaric acid, a substance produced naturally in small amounts by mammals, including humans.
- Calcium-D-glucarate demonstrates detoxification properties, supporting the excretion of potentially toxic compounds.
- Phase II detoxification facilitates excretion of chemical carcinogens, steroid hormones, and other lipid-soluble toxins via conjugation with glucuronic acid in the liver (glucuronidation), allowing water soluble excretion into the intestinal lumen.
- Calcium-D-glucarate has been shown to inhibit beta-glucuronidase, an enzyme produced by colonic microflora, capable of deconjugating bound toxins, making it possible for them to be reabsorbed rather than excreted.
- Elevated beta-glucuronidase activity has been associated with an increased risk for various cancers, particularly hormone-dependent cancers such as breast, prostate, and colon cancers (potentially due to accumulation of excess hormones and toxins).
- Calcium-D-glucarate’s inhibition of betaglucuronidase activity allows the body to successfully excrete excess hormones (such as oestrogens) before they can be reabsorbed, reactivated and recirculated within the body.
Warnings
Many drugs and hormones are metabolised in the liver via glucuronidation therefore, taking calcium-D-glucarate may increase elimination of these substances, possibly reducing their effectiveness.
Cal-D-Glucarate has not been extensively tested for its effects during pregnancy. Health practitioners may prefer to avoid its use during pregnancy or lactation, unless confident that its impact can be reasonably deemed to be safe or beneficial.
Pharmacist Tip
If you are suffering from heavy periods start taking ONE scoop TWICE daily to help with heavy bleeds.
